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DEVELOPMENT OF GENE THERAPY
Scientists are moving into gene therapy for diseases caused by bad or missing genes. Missing genes are now said to account for several cancers, including colon cancer.
Researchers at the National Institutes of Health took white blood cells from a young girl born with severe combined immune deficiency syndrome (SCIDS, also known as “boy in a bubble disease”). She was a sitting duck for any virus or bacterium that came along. She lacked the gene that makes an enzyme needed to keep white cells alive. The scientist took the normal gene she lacked from another human’s DNA and implanted it into the white cells they took from the girl. They then re-injected the white cells into the patient. At this writing, the youngster has produced a normal number of white blood cells for the first time in her life. But more time must pass before the experiment can be evaluated. Some scientists have criticized the experiment, saying that not enough is known about gene transfers in humans or their long-range effects.
Jeremy Rifkin, president of the Foundation on Economic Trends, has urged more caution in the whole genetic engineering enterprise. “In their mad dash for profit,” he says, “companies and scientists have given short shrift to problems that could have profound impact on human health. The more powerful technology that allows us to intervene in living creatures, the more powerful the long-term disruption. We are changing the genetic blueprint.”
Scientists are busy making the total human DNA molecule. They want to find the structure and location of every gene in that strand. The map of genes is called the genome.
Some scientists estimate that it will take 15 years and 3 billion dollars to pinpoint each of the 100,000 DNA genes. They fear the genome project will take money from smaller but critical basic research projects – the kind that Watson did as a young man.
Scientists favoring this project argue that having a complete map of genes will reveal the genetic component of every disease. They could then ferret out the genes for intelligence, mental diseases, susceptibility to infection, even emotional reactions and behaviors.
In 1996, new techniques were developed for identifying genes and their structure. A growing number of biologists think that the time will be cut short in approaching the full structure of DNA from human beings.
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