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MEDICATIONS OFTEN PRESCRIBED FOR PATIENTS WITH HEART DISEASE: DIGOXIN AND CALCIUM ANTAGONISTS
Calcium antagonists: These are drugs that block the entry of calcium into heart cells, and open up the heart’s and other blood vessels, slightly weakening the pumping action of the heart. They lower blood pressure and are quite effective at diminishing the frequency and severity of attacks of angina, especially if chest pain or discomfort occurs at rest or with minimal provocation. The drugs cause very few side effects except for rare headache or ankle swelling. However, there is not good evidence that calcium antagonists, unlike beta blockers, prolong life or prevent heart attacks. Nevertheless, they are frequently used in cases of severe or frequent chest pain or discomfort.
Digoxin: Digoxin, a drug derived from a species of the foxglove plant, has been used to treat heart disease for many centuries. It slightly strengthens the beating of the heart, and slows heart rate, especially in the irregular heartbeat condition known as atrial fibrillation (see page 157). Although it does not prolong life, it can decrease breathlessness and improve well-being in patients with heart failure, and can modestly reduce palpitations in atrial fibrillation. It can have side effects at higher doses, however, and its dose needs to be monitored regularly.
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