Cystone (Uricare)


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WHEN POISON CURES: TREATMENT WITH BOTOX
BOTOX is being tested widely for numerous disorders, including these:
– Large-muscle spasms. Usually these are side effects of a disease – stroke, head trauma, multiple sclerosis, spinal-cord injury, or cerebral palsy. They mostly affect the arms, legs, and neck. Dr. Brin has treated 16 patients for large-muscle spasms. Each improved, including Alyce Pollack of Fort Lee, New Jersey, who walked with crutches until November 1989, when her legs “just locked together.” In February 1990, Dr. Brin injected her thigh with BOTOX. “I had immediate relief,” she says. “I walked with my crutches again.” Dr. Brin says BOTOX could help other conditions that lead to cramps of large muscles. “Say, in the first few days of a stroke, one gets a spastic arm. If treated early, the arm could be saved immediately, with no therapy required later.”
– Dysphonia. This condition, in which a muscle cramp in the voice box keeps vocal cords open or shut tight, prevents speech. It struck Bill McNarney, 53, of Des Moines, Iowa, in 1986. By the end of the year, he says, “I sounded strangulated. I could not talk on the phone.” In 1988, he got help through Dr. Christy Ludlow, a speech pathologist at the National Institutes of Health (NIH) in Bethesda, Maryland. Doctors at NIH injected the toxin into Mr. McNarney’s cramped vocal-cord muscle. “By the summer and fall of 1990,” he says, “I could make phone calls.” Says Dr. Ludlow, “We’ve seen functional recovery in 14 percent of our patients – no full cures yet.”
– Stuttering and oral spasms. Dr. Ludlow and Dr. Brin have treated stuttering originating deep in the throat. They’ve also reduced oral spasms – involuntary moving of lips, tongue, jaw, and mouth that impedes chewing and swallowing.
– Tremors. Such shaking of hands, head, limbs, or body may result from Parkinson’s disease, caused by a brain malfunction, or from essential tremor, of unknown cause, which may run in families and affects about 5 million Americans. Dr. William Koller, chief neurologist at the University of Kansas Medical Center in Kansas City, Kansas, and Dr. Joseph Jankovic at Baylor Medical School in Houston are testing BOTOX against tremor along with Dr. Brin. “If it works,” Dr. Koller says, “it will help a lot of people.”
? Cerebral palsy. Dr. L. Andrew Koman, professor of orthopedic surgery at the Bowman Gray School of Medicine f Wake Forest University, Winston-Salem, North Carolina, tried BOTOX on 12 children with cerebral palsy. They had resorted to walking on their toes because their calf muscles were cramped. All but four benefited significantly, but, says Dr. Koman, “We need more study.”
? Writer’s cramp. This condition occurs when you use your hands too much and can be very painful. Dr. Mark Hallett, of the National Institutes of Health, has used BOTOX on more than 50 patients (writers, musicians, and others who steadily use their hands), and, he says, 80 percent have improved. “Writer’s cramp,” he says, “is a lot more common than realized. The disorder does not go away. But four of five patients show improvement.”
? Furrowed brow. Some of us frown so hard and so long that a furrow develops on the forehead between the eyes. It can be filled in with collagen, but, warns Dr. Jean Carruthers, an ophthalmologist at the University of British Columbia, blindness is a risk. With “major surgery,” she says, some physicians cut out the spastic or cramped muscles that support the furrow. She has eliminated the furrow instead by injecting the cramped muscles with BOTOX.
*48/266/5*

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