Quinine

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WATER BALANCE IN YOUR BODY: WATER REQUIREMENT, SOURCES, ETC
Water requirement
The daily water requirement is about 1 ml per kcal; a requirement of 2000 kcal necessitates a water intake of 2000 ml. Infants have proportionately greater water losses, and should be allowed about 150 ml (5 oz.) water for each 100 kcal. Thirst is a good guide for adequate fluid intake, except for sick persons and for infants.
Sources of water
The fluids we drink account for the chief intake of water. There is no harm in drinking water with meals provided it is not used to wash foods down without chewing them.
Foods contribute a fair amount of water.
Water also results from the oxidation of glucose, fatty acids, and amino acids. The amount of water produced in the body from metabolism is about 300 to 450 ml daily.
Water balance
Ordinarily the water sources to the body and the water losses from the body are in balance, as the following example shows:
Sources of Water ml Losses of Water ml
Water, tea, coffee 1100 Urine 1200
Milk (2 cups) 420 Feces 100
“Solid” foods 480 Skin and lungs 1000
Metabolic water 300 2300
2300
Clinical problems
Dehydration results when the intake is less than the body needs. This can occur when, for some reason, there is no food or fluid intake, or when the losses from the body are abnormally high: excessive perspiration because of marked activity in hot weather; severe diarrhea; vomiting; fever with increased losses through the skin; hemorrhage; severe burns with the accompanying water losses from the skin; uncontrolled diabetes with frequent urination. Dehydration is a serious medical problem requiring prompt attention. Fluids are given by mouth when possible; intravenous fluids are given when the patient is unable to take sufficient fluid by mouth. In dehydration there has often been loss of electrolytes as well so that these will require replacement with the water.
Edema is the accumulation water in the body. It occurs when the body is unable to excrete sodium in sufficient amounts. This is not unusual in diseases of the heart when the circulation is impaired, or when the kidneys are unable to excrete wastes normally. Edema also occurs following prolonged protein deficiency, because the tissues are no longer able to maintain normal water balance.
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