Femara (Letrozol)


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Femara (Letrozol)
FAT-SOLUBLE VITAMINS: VITAMIN E
Vitamin E activity is possessed by a number of compounds known as tocopherols.
Functions
Although vitamin E has been known since the 1920s its functions are still poorly understood. The principal role of vitamin E appears to be as an antioxidant. By accepting oxygen, vitamin E can prevent the oxidation of vitamin A in the intestinal tract, thus making vitamin A available for body use. Vitamin E also reduces the oxidation of the polyunsaturated fatty acids, thereby helping to maintain normal cell membranes. It protects the red blood cell against hemolysis. Vitamin E is required by animals, and presumably by humans, for the normal reproductive processes. It may have some function in the aging of cells.
Dietary allowances
The recommended allowance for vitamin E, expressed as alpha-tocopherol equivalents (?.?.), is 10 mg for men and 8 mg for women.
Food sources
Vitamin E is widely distributed in foods, with vegetable oils (corn, soy, safflower and cotton-seed), shortening, and margarines furnishing about two thirds of the day’s intake. Whole-grain cereals, legumes, nuts, and dark green vegetables are also good sources. Some commercial use is made of tocopherols as an additive to prevent or retard oxidation and rancidity.
Clinical problems
Deficiency of vitamin E in humans is unlikely except when diets are grossly lacking in many other nutrients. In infants with protein-calorie malnutrition vitamin E deficiency has been noted by increased hemolysis of red blood cells and a macrocytic anemia. The possibility of deficiency should be considered in premature infants and in patients who have a defect in the absorption of fats and fat-soluble vitamins.
Perhaps the chief problem associated with vitamin E is that many exaggerated and unproven claims have been made in the treatment of disease conditions. There is no reliable evidence that supports the claims that vitamin E is effective for the treatment or cure of muscular dystrophy, acne, ulcers, rheumatic fever, heart disease, and reproductive disorders. It is fortunate that vitamin E has not been shown to be toxic in view of the overuse of the vitamin as a result of these false claims.
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