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HIGH TECH MEDICINE: COMING OUR WAY
In 1953, in one of the great marbled meeting halls of the National Academy of Sciences in Washington, D.C., a young, thin, nervous man in his 20s told the most learned American men and women of science his astounding story of research into the hidden chemistry of life. An older scientist, who had undertaken to be my mentor, whispered to me, then a young reporter, “This is the greatest biological discovery of the 20th century.” And he was right.
That young man was James “Double Helix” Watson, an American who, with Francis Crick, an Englishman, gave the first correct description of DNA, the basic chemical of heredity. They said DNA consisted of two long chains of clusters of atoms spiraling like the strands of a twisted rope. The spiral, or double helix, taken from a human being contains the chemical blueprint to build a human being. Rat DNA has the manufacturing data to make a rat, and so on for all the animal and plant species we know. Their discovery triggered one of the greatest bursts of creative research in history. After nearly 40 years of diligent labor by thousands of researchers, we are now enjoying the payoffs, including these:
? We?re uncovering the chemical basis of mystery afflictions like muscular dystrophy and cystic fibrosis.
? We’re getting new and miraculous treatments for cancer, heart attacks, strokes, diabetes, hemophilia, AIDS, and dwarfism, to name a few.
? We?re creating biotechnology, a new multibillion-dollar industry to fashion those treatments.
? We will see medicines for mental disease; rare, deadly, inherited ailments like Huntington’s chorea, which killed folk singer Woody Guthrie; multiple sclerosis; arthritis; and even the common cold.
David Baltimore, Nobel Prize winner, says, “We’ve seen these blockbuster products come out amid tremendous scientific activity. It is extremely exciting. By the year 2000, we’ll have a whole new set of medicines. The situation is self-renewing.”
Carolyn Schmidt, an interior decorator from Darien, Connecticut, contracted an infection that destroyed her kidneys’ ability to clean toxic waste from her blood. Three times a week at home, Mrs. Schmidt hooks herself up to a machine that pumps her blood through a filter to remove the offending chemicals-and save her life. Finally, an artificial form of the hormone/protein erythropoietin (EPO) is injected into the venous line returning the blood to her body.
Healthy, working kidneys produce EPO, which prompts the body to make red blood cells. Her kidneys can’t do this, so Mrs. Schmidt’s blood becomes anemic-lacking in red blood cells. Before using this artificial EPO, she had blood transfusions, which are dangerous and expensive.
“I used to get tired and cold very easily,” Mrs. Schmidt says. “I forced myself to keep going. When I used EPO, I didn’t get short breath. I had red lips again. I bloomed. EPO makes the difference between sick and healthy. It really is a miracle drug.”
EPO is connected directly to Watson and Crick’s discovery in 1953. Scientists figured out that sections of the big DNA molecule correspond to genes-chemicals in the hearts of cells that control cell functions. We are made up of billions of cells, and our genes determine our size, shape, coloration, and much of how we think and feel. Genes also underlie many human diseases.
When Watson and Crick unlocked the chemical door to the secret of genes, scientists rushed in to unravel the secret code of DNA: the genetic code. Different stripes of DNA-which makes up the genes – tell the cell’s chemical factory to put together different proteins.
The basic technique: Isolate the DNA fragment of the special gene; make copies; inject the copies into certain bacteria, yeast, or mammalian cells; collect and purify this soup, which contains the needed protein. It’s called biotechnology. Such manipulations have revealed the genes – the chemical formula of the actual fragment of DNA – for muscular dystrophy, cystic fibrosis, Elephant Man’s disease, and Tay-Sachs disease, a hereditary affliction that destroys children’s brains.
The technology has also created Humilin – human insulin for diabetics, whose pancreas can’t make the hormone.
Without insulin, the body’s cells cannot burn sugar. Without insulin, a diabetic sinks into a coma and dies.
Until Eli Lilly and Co. marketed Humilin in 1982, diabetics relied on insulin from cows and pigs. Often their immune system rejected the foreign insulin, but not the human insulin.
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