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MIRACLE MEDICINES: GROWTH-STIMULATING HORMONE
Eli Lilly and Co. also makes human growth hormones, now injected into thousands of American children whose pituitary glands can’t make the growth-stimulating chemical. Without the hormone, they stay small. (Our genes determine our height. If a child has a normal pituitary gland, injections of artificial growth hormone won’t increase height. So don’t plan to produce a clan of basketball stars.)
Doctors at the North Shore University Hospital in Manhasset, New York, had remarkable but short-lived results with the hormone. Drs. W. Ted Brown and Fima Lifshitz injected the chemical into two children with progeria, a genetic disease that rapidly ages children’s bodies. At the chronological age of 15, they are 90 years old biologically. They suffer heart attacks and strokes. They remain under 4.5 feet tall. Their pinched faces look like masks. No hair grows on their heads. About 20 of these children are known worldwide.
Kevin Brown was 5 when his parents brought him from Cleveland to Dr. Brown. His biological age was somewhere around 40. Later he suffered a mild stroke. A few months later, Jessica Davis, 6, came to Dr. Brown from a suburb of Pittsburgh. Given daily injections of growth hormone at home, both children grew 1.5 inches in 3 months.
“We don’t know if we have lengthened their lives in any way yet,” Dr. Brown says. “But we’re excited, because this is the first positive result we have had.” Because this research is very demanding, progress moves slowly.
Doctors also have had great success using growth-stimulating hormone in otherwise healthy children who lack the natural hormone. A trip to Disney World proved a bitter disappointment for Ryan Fleckner of Huntington, New York, because he was not tall enough to go on the rides. Soon after, Dr. Lifshitz prescribed injections of growth hormone three times a week, and Ryan grew about 7 inches in a few short months. Again the complexity of the work has held back faster progress.
Dr. Daniel Rudman and his colleagues at the Medical College of Wisconsin at Milwaukee injected growth hormone into 12 men, ages 61 to 81, for 6 months. The artificial chemical increased their muscle mass, decreased the fat content of their bodies, and thickened their skin. The hormone appears to reverse these aspects of what was thought to be the inevitable process of aging.
*70/266/5*
